Pharmacokinetics and toxicity considerations for antibody-drug conjugates: an overview.

IF 1.9 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

Bioanalysis Pub Date : 2023-10-01 Epub Date: 2023-09-19 DOI:10.4155/bio-2023-0104

Siddhanth Hejmady, Rajesh Pradhan, Shobha Kumari, Meghna Pandey, Sunil K Dubey, Rajeev Taliyan

引用次数: 0

Abstract

Antibody-drug conjugates (ADCs) is one of the fastest-growing drug-delivery systems. It involves a monoclonal antibody conjugated with payload via a ligand that directly targets the expressive protein of diseased cell. Hence, it reduces systemic exposure and provides site-specific delivery along with reduced toxicity. Because of this advantage, researchers have gained interest in this novel system. ADCs have displayed great promise in drug delivery and biomedical applications. However, a lack of understanding exists on their mechanisms of biodistribution, metabolism and side effects. To gain a better understanding of the therapeutics, careful consideration of the pharmacokinetics and toxicity needs to be undertaken. In this review, different pharmacokinetics parameters including distribution, bioanalysis and heterogeneity are discussed for developing novel therapeutics.

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抗体-药物偶联物的药代动力学和毒性考虑：综述。

抗体药物偶联物（ADC）是发展最快的药物递送系统之一。它涉及通过直接靶向患病细胞表达蛋白的配体与有效载荷偶联的单克隆抗体。因此，它减少了全身暴露，并提供了位点特异性递送，同时降低了毒性。由于这一优势，研究人员对这种新型系统产生了兴趣。ADC在药物递送和生物医学应用方面显示出巨大的前景。然而，对它们的生物分布、代谢和副作用机制缺乏了解。为了更好地了解治疗方法，需要仔细考虑药物动力学和毒性。在这篇综述中，讨论了不同的药代动力学参数，包括分布、生物分析和异质性，以开发新的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioanalysis BIOCHEMICAL RESEARCH METHODS-CHEMISTRY, ANALYTICAL

CiteScore

3.30

自引率

16.70%

发文量

审稿时长

2 months

期刊介绍： Reliable data obtained from selective, sensitive and reproducible analysis of xenobiotics and biotics in biological samples is a fundamental and crucial part of every successful drug development program. The same principles can also apply to many other areas of research such as forensic science, toxicology and sports doping testing. The bioanalytical field incorporates sophisticated techniques linking sample preparation and advanced separations with MS and NMR detection systems, automation and robotics. Standards set by regulatory bodies regarding method development and validation increasingly define the boundaries between speed and quality. Bioanalysis is a progressive discipline for which the future holds many exciting opportunities to further reduce sample volumes, analysis cost and environmental impact, as well as to improve sensitivity, specificity, accuracy, efficiency, assay throughput, data quality, data handling and processing. The journal Bioanalysis focuses on the techniques and methods used for the detection or quantitative study of analytes in human or animal biological samples. Bioanalysis encourages the submission of articles describing forward-looking applications, including biosensors, microfluidics, miniaturized analytical devices, and new hyphenated and multi-dimensional techniques. Bioanalysis delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for the modern bioanalyst.