Estradiol enhances the mirtazapine effects on the expression of cocaine-induced locomotor sensitization in female rats.

IF 1.6 4区 心理学 Q3 BEHAVIORAL SCIENCES
Susana Barbosa-Méndez, Alberto Salazar-Juárez
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引用次数: 0

Abstract

Epidemiological studies have mentioned that cocaine use disorder (CUD) has increased in the last decade among women; these show endocrine and reproductive disorders and a high propensity to stress and depression disorders. Mirtazapine-a tetracyclic antidepressant-decreases cocaine-induced locomotor activity and locomotor sensitization in male rats. The objective of this study was to evaluate if estradiol alters the efficacy of mirtazapine to decrease cocaine-induced locomotor activity in sham and ovariectomized female rats. Three hundred and twenty adult female Wistar rats were assigned to three experimental protocols. For experiments, 1-3, female rats were daily dosed with 10 mg/kg of cocaine during the 10 days of induction and expression of locomotor sensitization. During drug withdrawal (30 days), cocaine was withdrawn and the groups received daily mirtazapine, estradiol, or saline. In addition, the females underwent sham or ovariectomy surgery. Tamoxifen was administered during the antagonism phase. After each administration, locomotor activity for each animal was recorded for 30 min in activity chambers. The dosage of mirtazapine reduces estradiol-induced enhancement in cocaine-dependent locomotor activity during the expression of locomotor sensitization in sham and ovariectomized female rats. As well as they showed that estradiol co-dosed with mirtazapine enhances the efficacy of mirtazapine to decrease cocaine-induced locomotor activity. Finally, tamoxifen enhanced the estradiol and mirtazapine-induced decrease in the cocaine motor effect in female rats. Mirtazapine may be considered an effective therapeutic option for the treatment of CUD in women, even in those who are on hormonal treatment or antidepressant therapy with estradiol.

雌二醇增强米氮平对雌性大鼠可卡因运动致敏表达的影响。
流行病学研究提到,在过去十年中,可卡因使用障碍(CUD)在妇女中有所增加;这些都显示出内分泌和生殖障碍,以及压力和抑郁障碍的高倾向。米氮平-一种四环抗抑郁药-降低雄性大鼠可卡因诱导的运动活性和运动致敏。本研究的目的是评估雌二醇是否会改变米氮平降低假手术和去卵巢雌性大鼠可卡因诱导的运动活性的效果。320只成年雌性Wistar大鼠被分配到三个实验方案中。实验中,1-3只雌性大鼠在运动致敏诱导和表达的10天内,每天给药10 mg/kg的可卡因。在停药期间(30天),停用可卡因,各组每天服用米氮平、雌二醇或生理盐水。此外,这些女性还接受了假卵巢切除术或卵巢切除术。在拮抗期给予他莫昔芬。每次给药后,在活动室记录每只动物30分钟的运动活动。在假手术和去卵巢雌性大鼠的运动致敏表达过程中,米氮平剂量降低雌二醇诱导的可卡因依赖运动活性增强。此外,他们还发现雌二醇与米氮平合用可以增强米氮平减少可卡因引起的运动活动的效果。最后,他莫昔芬增强雌二醇和米氮平诱导的雌性大鼠可卡因运动效应的减弱。米氮平可能被认为是治疗女性CUD的有效选择,即使对那些正在接受激素治疗或用雌二醇进行抗抑郁治疗的女性也是如此。
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来源期刊
Behavioural Pharmacology
Behavioural Pharmacology 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
84
审稿时长
6-12 weeks
期刊介绍: Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.
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