The rise of mechanical metamaterials: Auxetic constructs for skin wound healing.

IF 6.7 1区 工程技术 Q1 CELL & TISSUE ENGINEERING
Óscar Lecina-Tejero, María Ángeles Pérez, Elena García-Gareta, Carlos Borau
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引用次数: 2

Abstract

Auxetic materials are known for their unique ability to expand/contract in multiple directions when stretched/compressed. In other words, they exhibit a negative Poisson's ratio, which is usually positive for most of materials. This behavior appears in some biological tissues such as human skin, where it promotes wound healing by providing an enhanced mechanical support and facilitating cell migration. Skin tissue engineering has been a growing research topic in recent years, largely thanks to the rapid development of 3D printing techniques and technologies. The combination of computational studies with rapid manufacturing and tailored designs presents a huge potential for the future of personalized medicine. Overall, this review article provides a comprehensive overview of the current state of research on auxetic constructs for skin healing applications, highlighting the potential of auxetics as a promising treatment option for skin wounds. The article also identifies gaps in the current knowledge and suggests areas for future research. In particular, we discuss the designs, materials, manufacturing techniques, and also the computational and experimental studies on this topic.

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机械超材料的兴起:用于皮肤伤口愈合的辅助结构。
增塑剂材料以其在拉伸/压缩时向多个方向膨胀/收缩的独特能力而闻名。换句话说,它们的泊松比为负,而大多数材料的泊松比通常为正。这种行为出现在一些生物组织中,如人类皮肤,它通过提供增强的机械支持和促进细胞迁移来促进伤口愈合。近年来,由于3D打印技术和技术的快速发展,皮肤组织工程已经成为一个日益增长的研究课题。计算研究与快速制造和定制设计的结合为个性化医疗的未来提供了巨大的潜力。总之,这篇综述文章提供了一个全面的研究现状在皮肤愈合的应用,强调了皮肤愈合作为一个有前途的治疗选择的潜力。这篇文章还指出了当前知识中的差距,并提出了未来研究的领域。特别地,我们讨论了设计、材料、制造技术,以及关于这个主题的计算和实验研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Tissue Engineering
Journal of Tissue Engineering Engineering-Biomedical Engineering
CiteScore
11.60
自引率
4.90%
发文量
52
审稿时长
12 weeks
期刊介绍: The Journal of Tissue Engineering (JTE) is a peer-reviewed, open-access journal dedicated to scientific research in the field of tissue engineering and its clinical applications. Our journal encompasses a wide range of interests, from the fundamental aspects of stem cells and progenitor cells, including their expansion to viable numbers, to an in-depth understanding of their differentiation processes. Join us in exploring the latest advancements in tissue engineering and its clinical translation.
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