The CADM2 Gene and Behavior: A Phenome-Wide Scan in UK-Biobank.

IF 2.6 4区医学 Q2 BEHAVIORAL SCIENCES

Behavior Genetics Pub Date : 2022-09-01 Epub Date: 2022-07-22 DOI:10.1007/s10519-022-10109-8

Joëlle A Pasman, Zeli Chen, Dirk J A Smit, Jacqueline M Vink, Michel C Van Den Oever, Tommy Pattij, Taco J De Vries, Abdel Abdellaoui, Karin J H Verweij

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引用次数: 0

Abstract

The cell adhesion molecule 2 (CADM2) gene has appeared among the top associations in a wide range of genome-wide association studies (GWASs). This study aims to: (1) examine how widespread the role of CADM2 is in behavioural traits, and (2) investigate trait-specific effects on CADM2 expression levels across tissues. We conducted a phenome-wide association study in UK Biobank (N = 12,211-453,349) on 242 psycho-behavioral traits, both at the SNP and the gene-level. For comparison, we repeated the analyses for other large (and high LD) genes. We found significant associations between CADM2 and 50 traits (including cognitive, risk taking, and dietary traits), many more than for the comparison genes. We show that many trait associations are reduced when taking geographical stratification into account. S-Predixcan revealed that CADM2 expression in brain tissues was significantly associated with many traits; highly significant effects were also observed for lung, mammary, and adipose tissues. In conclusion, this study shows that the role of CADM2 extends to a wide range of psycho-behavioral traits, suggesting these traits may share a common biological denominator.

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CADM2 基因与行为：英国生物数据库中的表型全扫描。

细胞粘附分子 2（CADM2）基因在各种全基因组关联研究（GWASs）中都名列前茅。本研究旨在：(1) 研究 CADM2 在行为特质中的作用有多广泛；(2) 调查特质对 CADM2 在不同组织中表达水平的影响。我们在英国生物库（N = 12,211-453,349）中对 242 个心理行为特征进行了全表型关联研究，包括 SNP 和基因水平的研究。为了进行比较，我们对其他大型（高LD）基因进行了重复分析。我们发现，CADM2 与 50 个特质（包括认知、风险承担和饮食特质）之间存在显着关联，比对比基因多得多。我们发现，如果考虑到地理分层因素，许多性状的关联性会减弱。S-Predixcan显示，CADM2在脑组织中的表达与许多性状有显著关联；在肺、乳腺和脂肪组织中也观察到了高度显著的影响。总之，这项研究表明，CADM2 的作用延伸到一系列心理行为特征，这表明这些特征可能具有共同的生物学特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavior Genetics 生物-行为科学

CiteScore

4.90

自引率

7.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Behavior Genetics - the leading journal concerned with the genetic analysis of complex traits - is published in cooperation with the Behavior Genetics Association. This timely journal disseminates the most current original research on the inheritance and evolution of behavioral characteristics in man and other species. Contributions from eminent international researchers focus on both the application of various genetic perspectives to the study of behavioral characteristics and the influence of behavioral differences on the genetic structure of populations.