Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction.

IF 5.3 2区医学 Q1 PHYSIOLOGY

Physiology Pub Date : 2023-09-01 Epub Date: 2023-04-04 DOI:10.1152/physiol.00004.2023

Daniel Daou, Thomas G Gillette, Joseph A Hill

引用次数: 0

Abstract

Heart failure with preserved ejection fraction (HFpEF) is now the most common form of heart failure and a significant public health concern for which limited effective therapies exist. Inflammation triggered by comorbidity burden is a critical element of HFpEF pathophysiology. Here, we discuss evidence for comorbidity-driven systemic and myocardial inflammation and the mechanistic role of inflammation in pathological myocardial remodeling in HFpEF.

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射血分数保留型心力衰竭的炎症机制

射血分数保留型心力衰竭（HFpEF）是目前最常见的心力衰竭形式，也是一个重要的公共卫生问题，目前有效的治疗方法有限。合并症负担引发的炎症是 HFpEF 病理生理学的关键因素。在此，我们将讨论合并症驱动的全身和心肌炎症的证据，以及炎症在 HFpEF 病理心肌重塑中的机制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Physiology 医学-生理学

CiteScore

14.50

自引率

0.00%

发文量

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