A pan-cancer single-cell panorama of human natural killer cells.

IF 42.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2023-09-14 Epub Date: 2023-08-21 DOI:10.1016/j.cell.2023.07.034

Fei Tang, Jinhu Li, Lu Qi, Dongfang Liu, Yufei Bo, Shishang Qin, Yuhui Miao, Kezhuo Yu, Wenhong Hou, Jianan Li, Jirun Peng, Zhigang Tian, Linnan Zhu, Hui Peng, Dongfang Wang, Zemin Zhang

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引用次数: 5

Abstract

Natural killer (NK) cells play indispensable roles in innate immune responses against tumor progression. To depict their phenotypic and functional diversities in the tumor microenvironment, we perform integrative single-cell RNA sequencing analyses on NK cells from 716 patients with cancer, covering 24 cancer types. We observed heterogeneity in NK cell composition in a tumor-type-specific manner. Notably, we have identified a group of tumor-associated NK cells that are enriched in tumors, show impaired anti-tumor functions, and are associated with unfavorable prognosis and resistance to immunotherapy. Specific myeloid cell subpopulations, in particular LAMP3⁺ dendritic cells, appear to mediate the regulation of NK cell anti-tumor immunity. Our study provides insights into NK-cell-based cancer immunity and highlights potential clinical utilities of NK cell subsets as therapeutic targets.

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人类自然杀伤细胞的泛癌单细胞全景图。

自然杀伤细胞在抵抗肿瘤进展的先天免疫反应中发挥着不可或缺的作用。为了描述它们在肿瘤微环境中的表型和功能多样性，我们对716名癌症患者的NK细胞进行了整合的单细胞RNA测序分析，涵盖24种癌症类型。我们以肿瘤类型特异性的方式观察到NK细胞组成的异质性。值得注意的是，我们已经鉴定了一组肿瘤相关的NK细胞，这些细胞在肿瘤中富集，显示出抗肿瘤功能受损，并与不良预后和免疫疗法耐药性有关。特异性骨髓细胞亚群，特别是LAMP3+树突状细胞，似乎介导NK细胞抗肿瘤免疫的调节。我们的研究为基于NK细胞的癌症免疫提供了见解，并强调了NK细胞亚群作为治疗靶点的潜在临床实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.