{"title":"<i>Candida auris</i> Genetics and Emergence.","authors":"Anuradha Chowdhary, Kusum Jain, Neeraj Chauhan","doi":"10.1146/annurev-micro-032521-015858","DOIUrl":null,"url":null,"abstract":"<p><p><i>Candida auris</i> is a multidrug-resistant fungal pathogen that presents a serious threat to global human health. Since the first reported case in 2009 in Japan, <i>C. auris</i> infections have been reported in more than 40 countries, with mortality rates between 30% and 60%. In addition, <i>C. auris</i> has the potential to cause outbreaks in health care settings, especially in nursing homes for elderly patients, owing to its efficient transmission via skin-to-skin contact. Most importantly, <i>C. auris</i> is the first fungal pathogen to show pronounced and sometimes untreatable clinical drug resistance to all known antifungal classes, including azoles, amphotericin B, and echinocandins. In this review, we explore the causes of the rapid spread of <i>C. auris</i>. We also highlight its genome organization and drug resistance mechanisms and propose future research directions that should be undertaken to curb the spread of this multidrug-resistant pathogen.</p>","PeriodicalId":7946,"journal":{"name":"Annual review of microbiology","volume":"77 ","pages":"583-602"},"PeriodicalIF":8.5000,"publicationDate":"2023-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"6","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annual review of microbiology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1146/annurev-micro-032521-015858","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/7/5 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 6
Abstract
Candida auris is a multidrug-resistant fungal pathogen that presents a serious threat to global human health. Since the first reported case in 2009 in Japan, C. auris infections have been reported in more than 40 countries, with mortality rates between 30% and 60%. In addition, C. auris has the potential to cause outbreaks in health care settings, especially in nursing homes for elderly patients, owing to its efficient transmission via skin-to-skin contact. Most importantly, C. auris is the first fungal pathogen to show pronounced and sometimes untreatable clinical drug resistance to all known antifungal classes, including azoles, amphotericin B, and echinocandins. In this review, we explore the causes of the rapid spread of C. auris. We also highlight its genome organization and drug resistance mechanisms and propose future research directions that should be undertaken to curb the spread of this multidrug-resistant pathogen.
期刊介绍：
Annual Review of Microbiology is a Medical and Microbiology Journal and published by Annual Reviews Inc. The Annual Review of Microbiology, in publication since 1947, covers significant developments in the field of microbiology, encompassing bacteria, archaea, viruses, and unicellular eukaryotes. The current volume of this journal has been converted from gated to open access through Annual Reviews' Subscribe to Open program, with all articles published under a CC BY license. The Impact Factor of Annual Review of Microbiology is 10.242 (2024) Impact factor. The Annual Review of Microbiology Journal is Indexed with Pubmed, Scopus, UGC (University Grants Commission).
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