Three Cases of Myoclonus Secondary to Ciprofloxacin: "Ciproclonus".

IF 0.8 4区医学 Q4 CLINICAL NEUROLOGY

Clinical Neuropharmacology Pub Date : 2023-09-01 Epub Date: 2023-07-26 DOI:10.1097/WNF.0000000000000565

Hamna Javed, Hossam Tharwat Ali, Ziad Ashraf Soliman, Ana Leticia Fornari Caprara, Jamir Pitton Rissardo

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Abstract

Objectives: Ciprofloxacin is a fluoroquinolone that is used for bacterial infections involving different systems. In some cases, ciprofloxacin was reported to induce myoclonus.

Methods: We performed a chart review of 3 patients with myoclonus secondary to ciprofloxacin and reviewed the literature for similar cases. Written consent for publication was obtained from each patient, and their identities were concealed for ethical reasons.

Results: We describe 3 cases of myoclonus secondary to ciprofloxacin, 2 males and a female aged 61, 26, and 48 years, respectively. The myoclonus appeared within 3 days of ciprofloxacin intake. In all 3 cases, ciprofloxacin was prescribed for urinary tract infection. Electroencephalogram and neuroimaging studies were normal and possible causes were excluded. Thus, ciprofloxacin was believed to be the underlying cause and hence it was withdrawn. The patients had complete recovery on follow-up.

Conclusions: Although ciprofloxacin is widely prescribed for different infections, only 13 cases were reported to develop myoclonus secondary to ciprofloxacin. The mean age of patients was 62 years. Fifty-four percent of cases were males. Cessation of ciprofloxacin was the most common management course. All individuals fully recovered after ciprofloxacin withdrawal. The mechanism of ciprofloxacin-induced myoclonus is probably associated with γ-aminobutyric acid and glutamate pathways.

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环丙沙星继发肌阵挛3例。

目的：环丙沙星是一种用于不同系统细菌感染的氟喹诺酮类药物。在某些情况下，据报道环丙沙星可诱发肌阵挛。方法：我们对3例环丙沙星继发性肌阵挛患者进行了图表回顾，并回顾了类似病例的文献。每个患者都获得了发表的书面同意书，出于道德原因，他们的身份被隐瞒了。结果：我们描述了3例继发于环丙沙星的肌阵挛，男2例，女1例，年龄分别为61岁、26岁和48岁。肌阵挛在摄入环丙沙星后3天内出现。在所有3例病例中，均使用环丙沙星治疗尿路感染。脑电图和神经影像学研究正常，排除了可能的原因。因此，环丙沙星被认为是根本原因，因此被停用。患者在随访中完全康复。结论：尽管环丙沙星被广泛用于治疗不同的感染，但据报道只有13例发生继发于环丙沙星的肌阵挛。患者的平均年龄为62岁。54%的病例是男性。停药环丙沙星是最常见的治疗方案。所有个体在停药环丙沙星后完全康复。环丙沙星引起肌阵挛的机制可能与γ-氨基丁酸和谷氨酸途径有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuropharmacology 医学-临床神经学

CiteScore

1.20

自引率

10.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Neuropharmacology is a peer-reviewed journal devoted to the pharmacology of the nervous system in its broadest sense. Coverage ranges from such basic aspects as mechanisms of action, structure-activity relationships, and drug metabolism and pharmacokinetics, to practical clinical problems such as drug interactions, drug toxicity, and therapy for specific syndromes and symptoms. The journal publishes original articles and brief reports, invited and submitted reviews, and letters to the editor. A regular feature is the Patient Management Series: in-depth case presentations with clinical questions and answers.