Comparative Analysis of Anticancer and Antibacterial Activities among Seven Trametes Species.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01 DOI:10.1080/12298093.2023.2247218

Ha Thi Kim Nguyen, Jiwon Lee, Yejin Park, Hyon Jin Park, Soon Kil Ahn, Jae Kwang Kim, Dong-Ku Kang, Minkyeong Kim, Chorong Ahn, Changmu Kim, Jaehyuk Choi

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Abstract

Species in the genus Trametes (Basidiomycota, Polyporales) have been used in natural medicine for a long time. Many studies reported that mycelia or fruiting bodies of Trametes spp. exhibited effects of antioxidant, anti-inflammatory, anticancer, and antimicrobial activities. However, comparative analysis in this genus is scarce due to limitation of morphological identification and the sample number. In this study, the 19 strains of seven Trametes species were chosen to generate a five-gene-based phylogeny with the 31 global references. In addition, 39 culture extracts were prepared for 13 strains to test for anticancer and antibacterial activities. Strong anticancer activities were found in several extracts from T. hirsuta and T. suaveolens. Anticancer activities of T. suaveolens, T. cf. junipericola and T. trogii were first described here. The antibacterial ability of T. versicolor and T. hirsuta extracts has been confirmed. The antibacterial activities of T. suaveolens have been reported at the first time in this study. These results suggest an efficient application of the genus Trametes as the drug resources especially for anticancer agents.

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7种蕨类植物抗癌和抗菌活性的比较分析。

担子菌属(担子菌门，多孢子菌门)的种类已被广泛应用于天然药物中。许多研究报道了真菌菌丝或子实体具有抗氧化、抗炎、抗癌和抗菌活性。然而，由于形态鉴定和样本数量的限制，对该属植物的比较分析很少。在本研究中，我们选择了7个Trametes物种的19个菌株，与31个全球参考文献建立了一个基于5个基因的系统发育关系。另外，对13株菌株制备了39种培养提取物，并对其进行了抗癌和抗菌活性试验。毛毡毛毡和紫毡毛毡的几种提取物均有较强的抗癌活性。本文首次报道了甜葡萄球菌(T. suaveolens)、杜松子酸葡萄球菌(T. cf. junipericola)和trogii的抗癌活性。已经证实了花斑t和毛t提取物的抑菌作用。本研究首次报道了suaveolens的抑菌活性。这些结果提示了该属植物作为药物资源特别是抗癌药物的有效利用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.