Immunomodulatory Strategies for Spinal Cord Injury.

Jonghyuck Park
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Abstract

Neuroinflammation is a key secondary event after spinal cord injury (SCI) and can increase barriers to regeneration, leading to various neurological disorders. Infiltrated hematogenous innate immune cells into the injured site are considered the main effector cells of the inflammatory responses after SCI. Glucocorticoids were the standard of care for spinal cord trauma for years due to their anti-inflammatory properties yet were also associated with unwanted side effects. While the administration of glucocorticoids is controversial, immunomodulatory strategies that limit inflammatory responses provide the potential therapeutic approaches to promote functional regeneration following SCI. Herein, we will discuss emerging therapeutic strategies to modulate inflammatory responses to enhance nerve recovery after spinal cord trauma.

脊髓损伤的免疫调节策略。
神经炎症是脊髓损伤(SCI)后重要的继发性事件,可增加再生障碍,导致各种神经系统疾病。浸润到损伤部位的造血先天免疫细胞被认为是脊髓损伤后炎症反应的主要效应细胞。由于其抗炎特性,糖皮质激素多年来一直是脊髓创伤的标准治疗方法,但也与不良副作用有关。虽然糖皮质激素的使用存在争议,但限制炎症反应的免疫调节策略为促进脊髓损伤后的功能再生提供了潜在的治疗方法。在这里,我们将讨论新兴的治疗策略来调节炎症反应,以增强脊髓创伤后神经的恢复。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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