Effect of intraperitoneal magnesium sulfate in the prevention of postoperative pain in daycare laparoscopic cholecystectomy - A prospective randomized controlled trial.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-05-01 DOI:10.4103/ijp.ijp_827_22

Gorle Chaitanya Sravanthi, Kishore Abuji, Shiv Lal Soni, Satish Subbiah Nagaraj, Akhilesh Sharma, Anudeep Jafra, Cherring Tandup, Kailash Chand Kurdia, Divya Dahiya

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Abstract

This study evaluated the efficacy of intraperitoneal magnesium sulfate (MgSO₄) in preventing postoperative pain after elective laparoscopic cholecystectomy (LC). It is a prospective, double-blinded, placebo-controlled, randomized trial which included 64 patients who underwent LC. Patients were equally randomized into Groups A and B. MgSO₄ and normal saline were instilled in subdiaphragmatic space in Groups A and B, respectively, after creating pneumoperitoneum and before starting dissection. The Visual analogue Scale (VAS) was used to determine postoperative pain. Patients who received intraperitoneal MgSO₄ had lower average VAS scores for the first 6 h postoperatively, and also, the time for the requirement of first analgesic was longer (3.6 ± 0.4 vs. 2.3 ± 1.0 h). The incidence of vomiting and the requirement for rescue antiemetic was also lower in Group A. Intraperitoneal instillation of MgSO₄ reduces postoperative pain and vomiting following elective LC without incurring additional side effects.

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腹膜内硫酸镁预防日托腹腔镜胆囊切除术后疼痛的作用——一项前瞻性随机对照试验。

本研究评估了腹膜内硫酸镁（MgSO4）预防选择性腹腔镜胆囊切除术（LC）后疼痛的疗效。这是一项前瞻性、双盲、安慰剂对照、随机试验，包括64名接受LC的患者。患者被平等地随机分为a组和B组。在形成气腹后和开始剥离前，分别在a组和B组的膈下间隙滴注MgSO4和生理盐水。视觉模拟量表（VAS）用于确定术后疼痛。接受腹膜内MgSO4治疗的患者在术后前6小时的平均VAS评分较低，而且需要第一次镇痛的时间较长（3.6±0.4 vs.2.3±1.0小时）。A组的呕吐发生率和抢救止吐剂的需求也较低。腹膜内滴注MgSO4可以减少选择性LC术后的疼痛和呕吐，而不会产生额外的副作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.