Children's Adherence to Antiretroviral Therapy and Associated Factors: Multicenter Cross-Sectional Study.

IF 1.5 Q4 INFECTIOUS DISEASES

HIV AIDS-Research and Palliative Care Pub Date : 2023-01-01 DOI:10.2147/HIV.S407105

Getahun B Gemechu, Habtemu Hebo, Zarihun Kura

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引用次数: 0

Abstract

Background: Poor adherence to antiretroviral therapy (ART) causes drug resistance, treatment failure and death. Studies conducted among children below 15 years were limited in Ethiopia in general and in the study area. Therefore, this study aimed to assess the status of children's adherence to ART and associated factors in the study area.

Methods: We conducted a facility-based cross-sectional study from April 1 to May 10, 2020 by including 282 children <15 years. All children who received ART for at least one month and attend ART clinic during data collection period were consecutively recruited. Face-to-face interview was conducted using a standardized questionnaire. Both bivariate and multivariate logistic regression were performed. Adherence and exposure variables (i.e., sociodemographic and reason for missing) were measured by the caregivers/children's report of a one-month recall of missed doses.

Results: Among 282 caregivers included with their children, 226 (80.2%) were females (mean age = 38.6 and SD = 12.35) and half (50%) of children were females. Two hundred forty six (87.2%) children were aged between 5-14 years (mean age = 8.5 and SD = 2.64), and 87.2% were adhered (≥95%) to ART in the month prior to the interview. Children whose caregivers were residing in urban were 3.3 (95% CI: 1.17, 9.63) times more adherent to ART than their counterparties. Children whose caregivers were biological parents were 2.37 (95% CI: 1.59, 3.3) times more adherent than children with non-biological parents. Children with knowledgeable caregivers about ART were 4.5 (95% CI: 1.79, 9.8) times more adherent to ART.

Conclusion and recommendation: Children's adherence to ART in our study area was sub optimal. Biological caregivers, residing in urban and being knowledgeable about ART facilitate adherence to ART. Adherence counseling targeting non-biological parents and for those who come from rural areas were recommended.

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儿童抗逆转录病毒治疗依从性及相关因素:多中心横断面研究。

背景:抗逆转录病毒治疗(ART)依从性差导致耐药、治疗失败和死亡。在埃塞俄比亚和研究地区，对15岁以下儿童进行的研究总体上是有限的。因此，本研究旨在评估研究地区儿童抗逆转录病毒治疗依从性状况及相关因素。方法:我们于2020年4月1日至5月10日对282名儿童进行了一项基于设施的横断面研究。结果:282名带孩子的照顾者中，226名(80.2%)为女性(平均年龄为38.6岁，SD = 12.35)，一半(50%)的儿童为女性。246例(87.2%)儿童年龄在5-14岁之间(平均年龄= 8.5,SD = 2.64)， 87.2%(≥95%)在访谈前一个月坚持抗逆转录病毒治疗。照顾者居住在城市的儿童对ART的依从性是其对手的3.3倍(95% CI: 1.17, 9.63)。照顾者为亲生父母的儿童的依从性是非亲生父母儿童的2.37倍(95% CI: 1.59, 3.3)。有知识渊博的护理人员的儿童对ART的依从性是4.5倍(95% CI: 1.79, 9.8)。结论和建议:在我们的研究区域，儿童对抗逆转录病毒治疗的依从性并不理想。居住在城市并了解抗逆转录病毒治疗的生物护理人员有助于坚持抗逆转录病毒治疗。建议针对非亲生父母和来自农村地区的人进行依从性咨询。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

HIV AIDS-Research and Palliative Care INFECTIOUS DISEASES-

CiteScore

3.00

自引率

6.70%

发文量

审稿时长

16 weeks

期刊介绍： About Dove Medical Press Dove Medical Press Ltd is part of Taylor & Francis Group, the Academic Publishing Division of Informa PLC. We specialize in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine. Dove Medical Press was founded in 2003 with the objective of combining the highest editorial standards with the ''best of breed'' new publishing technologies. We have offices in Manchester and London in the United Kingdom, representatives in Princeton, New Jersey in the United States, and our editorial offices are in Auckland, New Zealand. Dr Scott Fraser is our Medical Director based in the UK. He has been in full time clinical practice for over 20 years as well as having an active research interest.