Head and neck cancer treatment in the era of molecular medicine.

2区医学 Q1 Medicine

Advances in Cancer Research Pub Date : 2023-01-01 Epub Date: 2023-04-12 DOI:10.1016/bs.acr.2023.03.004

Subramanya Pandruvada, Remi Kessler, Ann Thai

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引用次数: 1

Abstract

Head and neck cancers are a heterogeneous group of highly aggressive tumors and collectively represent the sixth most common cancer worldwide. Most head and neck cancers are squamous cell carcinomas (HNSCCs). Current multimodal treatment concepts combine surgery, chemotherapy, irradiation, immunotherapy, and targeted therapeutics. Recent scientific advancements have enabled a more precise molecular characterization of HNSCC and revealed novel therapeutic targets and prognostic/predictive biomarkers. Notably, HNSCC is characterized by complex relations between stromal, epithelial, and immune cells within the tumor microenvironment (TME). The TME consists of different subsets of immune cells that infiltrate the tumors and interact with the tumor cells or with each other. Understanding multiple pivotal factors in HNSCC tumorigenesis and tumor progression may help define novel targets and develop more effective therapies for patients. This review provides a comprehensive overview of the latest advances in the molecular biology of HNSCC and their effects on clinical oncology; it is meant for a broad readership in the head and neck cancers field.

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癌症分子医学时代的头颈部治疗。

头颈癌是一组高度侵袭性的异质性肿瘤，是全球第六大最常见的癌症。大多数头颈癌是鳞状细胞癌（HNSCC）。目前的多模式治疗概念结合了手术、化疗、放疗、免疫疗法和靶向治疗。最近的科学进步使HNSCC能够更精确地进行分子表征，并揭示了新的治疗靶点和预后/预测生物标志物。值得注意的是，HNSCC的特征是肿瘤微环境（TME）中基质细胞、上皮细胞和免疫细胞之间的复杂关系。TME由不同的免疫细胞亚群组成，这些免疫细胞浸润肿瘤并与肿瘤细胞相互作用或相互作用。了解HNSCC肿瘤发生和肿瘤进展的多种关键因素可能有助于确定新的靶点，并为患者开发更有效的治疗方法。本文综述了HNSCC分子生物学的最新进展及其对临床肿瘤学的影响；它是为头颈癌领域的广大读者准备的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Cancer Research 医学-肿瘤学

CiteScore

10.00

自引率

0.00%

发文量

期刊介绍： Advances in Cancer Research (ACR) has covered a remarkable period of discovery that encompasses the beginning of the revolution in biology. Advances in Cancer Research (ACR) has covered a remarkable period of discovery that encompasses the beginning of the revolution in biology. The first ACR volume came out in the year that Watson and Crick reported on the central dogma of biology, the DNA double helix. In the first 100 volumes are found many contributions by some of those who helped shape the revolution and who made many of the remarkable discoveries in cancer research that have developed from it.