Mitochondria-derived peptides in healthy ageing and therapy of age-related diseases.

3区生物学 Q1 Biochemistry, Genetics and Molecular Biology

Advances in protein chemistry and structural biology Pub Date : 2023-01-01 DOI:10.1016/bs.apcsb.2023.02.015

Siarhei A Dabravolski

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引用次数: 0

Abstract

Mitochondrial-derived peptides (MDPs) are small bioactive peptides encoded by mitochondrial DNA and involved in various stress-protecting mechanisms. To date, eight mitochondrial-derived peptides have been identified: MOTS-c sequence is hidden in the 12 S rRNA gene (MT-RNR1), and the other 7 (humanin and small humanin-like peptides 1-6) are encoded by the 16 S rRNA (MT-RNR2) gene. While the anti-apoptotic, anti-inflammatory and cardioprotective activities of MDPs are well described, recent research suggests that MDPs are sensitive metabolic sensors, closely connected with mtDNA mutation-associated diseases and age-associated metabolic disorders. In this chapter, we focus on the recent progress in understanding the metabolo-protective properties of MDPs, their role in maintenance of the cellular and mitochondrial homeostasis associated with age-related diseases: Alzheimer's disease, cognitive decline, macular degeneration and cataracts. Also, we will discuss MDPs-based and MDPs-targeted interventions to treat age-related diseases and extend a healthy lifespan.

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线粒体衍生肽在健康衰老和年龄相关疾病的治疗中的作用。

线粒体衍生肽(MDPs)是由线粒体DNA编码的小生物活性肽，参与多种应激保护机制。迄今为止，已经鉴定出8种线粒体衍生肽:MOTS-c序列隐藏在12s rRNA基因(MT-RNR1)中，另外7种(humanin和小人源肽1-6)由16s rRNA (MT-RNR2)基因编码。虽然MDPs的抗凋亡、抗炎和心脏保护活性已被很好地描述，但最近的研究表明，MDPs是敏感的代谢传感器，与mtDNA突变相关疾病和年龄相关代谢紊乱密切相关。在本章中，我们将重点介绍MDPs代谢保护特性的最新进展，以及它们在维持与年龄相关疾病(阿尔茨海默病、认知能力下降、黄斑变性和白内障)相关的细胞和线粒体稳态中的作用。此外，我们将讨论以mdps为基础和以mdps为目标的干预措施，以治疗与年龄有关的疾病并延长健康寿命。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in protein chemistry and structural biology BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

7.40

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Published continuously since 1944, The Advances in Protein Chemistry and Structural Biology series has been the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics.