Anesthesia and Cancer: Something More than Avoiding Stress Response.

IF 3.8 4区医学 Q2 GENETICS & HEREDITY

Current gene therapy Pub Date : 2023-01-01 DOI:10.2174/1566523223666230328165109

Aida Raigon Ponferrada, Salvador Romero Molina, Juan Carlos Molina Ruiz, Josefa Gomez Maldonado, Jose Luis Guerrero Orriach

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引用次数: 0

Abstract

Currently, an increasing prevalence has been reported in incidences of tumor pathologies. The influence of anesthetics drugs has been the subject of numerous studies. It has been reported that the use of certain drugs may have an impact on prognosis and survival. By investigating the action of these drugs on different metabolic pathways and their mechanisms of action, we can better understand how they influence various hallmarks of carcinogenesis and determine their potential impact on cancer progression. Some of the action pathways are widely known within oncology, being targets of specific treatments, such as PI3k/AKT/mTOR, EGFR, and Wnt/ β-catenin. This review performs a thorough dissection of the interaction between anesthetic drugs and oncological cell lines through cell signaling pathways and genetic, immune, and transcriptomic pathways. Through these underlying mechanisms, it aims to clarify the effect of the choice of anesthetic drug and its potential influence on the prognosis of oncological surgery.

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麻醉和癌症:不仅仅是避免应激反应。

目前，肿瘤病理的发病率越来越高。麻醉药物的影响一直是许多研究的主题。据报道，某些药物的使用可能对预后和生存有影响。通过研究这些药物对不同代谢途径的作用及其作用机制，我们可以更好地了解它们如何影响各种致癌标志，并确定它们对癌症进展的潜在影响。一些作用途径在肿瘤学中广为人知，是特定治疗的靶点，如PI3k/AKT/mTOR, EGFR和Wnt/ β-catenin。本综述通过细胞信号通路、遗传、免疫和转录组学途径对麻醉药物与肿瘤细胞系之间的相互作用进行了全面的剖析。通过这些潜在的机制，旨在阐明麻醉药物选择的影响及其对肿瘤手术预后的潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current gene therapy 医学-遗传学

CiteScore

6.70

自引率

2.80%

发文量

期刊介绍： Current Gene Therapy is a bi-monthly peer-reviewed journal aimed at academic and industrial scientists with an interest in major topics concerning basic research and clinical applications of gene and cell therapy of diseases. Cell therapy manuscripts can also include application in diseases when cells have been genetically modified. Current Gene Therapy publishes full-length/mini reviews and original research on the latest developments in gene transfer and gene expression analysis, vector development, cellular genetic engineering, animal models and human clinical applications of gene and cell therapy for the treatment of diseases. Current Gene Therapy publishes reviews and original research containing experimental data on gene and cell therapy. The journal also includes manuscripts on technological advances, ethical and regulatory considerations of gene and cell therapy. Reviews should provide the reader with a comprehensive assessment of any area of experimental biology applied to molecular medicine that is not only of significance within a particular field of gene therapy and cell therapy but also of interest to investigators in other fields. Authors are encouraged to provide their own assessment and vision for future advances. Reviews are also welcome on late breaking discoveries on which substantial literature has not yet been amassed. Such reviews provide a forum for sharply focused topics of recent experimental investigations in gene therapy primarily to make these results accessible to both clinical and basic researchers. Manuscripts containing experimental data should be original data, not previously published.