The efficacy of hydrogel containing zinc oxide-loaded and minocycline serum albumin nanopartical in the treatment of peri-implantitis.

IF 2.2 3区医学

Medicina oral, patologia oral y cirugia bucal Pub Date : 2023-09-01 DOI:10.4317/medoral.25890

X Li, C Yuan, Q Chen, Q Xue, J Mou, P Wang

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引用次数: 0

Abstract

Background: We conducted this animal study to assess the efficacy of the novel hydrogel containing zinc oxide-loaded and minocycline serum albumin nanoparticals (Mino-ZnO@Alb NPs) on peri-implantitis in an experimental mouse model.

Material and methods: Mino-ZnO@Alb NPs was prepared as previously reported. The peri-implantitis model was successfully established in rats, and the rats were divided into three groups randomly: Mino-ZnO@Alb NPs (Mino-ZnO) group, minocycline group, and untreated group. Four weeks later, clinical and radiographic assessments were performed to evaluate soft tissue inflammation and bone resorption level. Histologic analysis was performed to estimate the amount of remaining supporting bone tissue (SBT) around implants. ELISA tests were used to determine the concentration of inflammation factor interleukin-1-beta (IL-1β) and anti-inflammation factor tumor necrosis factor-alpha (TNF-α) around implants.

Results: After one month, the Mino-ZnO group showed better results than the other two groups in regards to the results of bleeding on probing, probing pocket depth, bleeding index and gingival index. X-ray showed that SBT at mesial and distal sites around implants in the other two groups was significantly lower compared with that of Mino-ZnO group. The quantity of osteoclasts in peri-implant tissues of the Mino-ZnO group was less than that in the minocycline and untreated groups. IL-1β in the Mino-ZnO group was lower than that in the other two groups. TNF-α level was the opposite.

Conclusions: Mino-ZnO@Alb NPs can effectively treat peri-implantitis and promote soft tissue healing, and may act as a promising product.

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氧化锌载米诺环素血清白蛋白纳米颗粒水凝胶治疗种植体周围炎的疗效观察。

背景:我们进行了这项动物研究，以评估含有氧化锌负载和米诺环素血清白蛋白纳米颗粒(Mino-ZnO@Alb NPs)的新型水凝胶在实验小鼠模型中对种植周围炎的疗效。材料和方法:Mino-ZnO@Alb NPs按先前报道制备。成功建立大鼠种植体周围炎模型，将大鼠随机分为Mino-ZnO@Alb NPs (Mino-ZnO)组、米诺环素组和未给药组。4周后，进行临床和影像学评估软组织炎症和骨吸收水平。进行组织学分析以估计种植体周围剩余支撑骨组织(SBT)的数量。采用ELISA法检测种植体周围炎症因子白细胞介素-1- β (IL-1β)和抗炎症因子肿瘤坏死因子α (TNF-α)的浓度。结果:1个月后，纳米氧化锌组在探诊出血、探诊袋深度、出血指数和牙龈指数方面均优于其他两组。x线显示，另外两组种植体周围中、远端部位的SBT均明显低于Mino-ZnO组。纳米氧化锌组种植体周围组织中破骨细胞数量少于米诺环素组和未处理组。纳米氧化锌组IL-1β明显低于其他两组。TNF-α水平则相反。结论:Mino-ZnO@Alb NPs能有效治疗种植体周围炎，促进软组织愈合，可能是一种有前景的产品。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina oral, patologia oral y cirugia bucal Medicine-Surgery

CiteScore

4.50

自引率

0.00%

发文量

期刊介绍： 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology