Peptide YY inhibits transcription and replication of hepatitis B virus by suppressing promoter/enhancer activity.

IF 1.9 4区医学 Q3 GENETICS & HEREDITY

Virus Genes Pub Date : 2023-10-01 Epub Date: 2023-06-28 DOI:10.1007/s11262-023-02017-8

Xiaolun Xu, Weiping Zhou, Xing Tian, Zhongjia Jiang, Xuanhe Fu, Jun Cao, Ye Sun, Biao Yang, Xueqian Li, Yanting Li, Chunmeng Zhang, Guangyan Liu

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引用次数: 0

Abstract

Hepatitis B virus (HBV) infection is a noteworthy cause of liver diseases, especially cirrhosis and hepatocellular carcinomas. However, the interaction between the host and HBV has not been fully elucidated. Peptide YY (PYY) is a 36-amino-acid gastrointestinal hormone that is mainly involved in the regulation of the human digestive system. This study found that PYY expression was reduced in HBV-expressing hepatocytes and HBV patients. Overexpression of PYY could significantly inhibit HBV RNA, DNA levels, and the secretion of HBsAg. In addition, PYY inhibits HBV RNA dependent on transcription through reducing the activities of CP/Enh I/II, SP1 and SP2. Meanwhile, PYY blocks HBV replication independent on core, polymerase protein and ε structure of pregenomic RNA. These results suggest that PYY can impair HBV replication by suppressing viral promoters/enhancers in hepatocytes. Our data shed light on a novel role for PYY as anti-HBV restriction factor.

Abstract Image

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肽YY通过抑制启动子/增强子活性来抑制乙型肝炎病毒的转录和复制。

乙型肝炎病毒（HBV）感染是肝脏疾病的一个值得注意的原因，尤其是肝硬化和肝细胞癌。然而，宿主与HBV之间的相互作用尚未完全阐明。肽YY（PYY）是一种36个氨基酸的胃肠激素，主要参与人体消化系统的调节。本研究发现PYY在表达HBV的肝细胞和HBV患者中的表达减少。PYY的过表达可显著抑制HBV RNA、DNA水平和HBsAg的分泌。此外，PYY通过降低CP/Enh I/II、SP1和SP2的活性来抑制HBV RNA依赖性转录。同时，PYY阻断HBV复制独立于核心、聚合酶蛋白和前基因组RNA的ε结构。这些结果表明PYY可以通过抑制肝细胞中的病毒启动子/增强子来损害HBV的复制。我们的数据揭示了PYY作为抗HBV限制因子的新作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Virus Genes 医学-病毒学

CiteScore

3.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Viruses are convenient models for the elucidation of life processes. The study of viruses is again on the cutting edge of biological sciences: systems biology, genomics, proteomics, metagenomics, using the newest most powerful tools. Huge amounts of new details on virus interactions with the cell, other pathogens and the hosts – animal (including human), insect, fungal, plant, bacterial, and archaeal - and their role in infection and disease are forthcoming in perplexing details requiring analysis and comments. Virus Genes is dedicated to the publication of studies on the structure and function of viruses and their genes, the molecular and systems interactions with the host and all applications derived thereof, providing a forum for the analysis of data and discussion of its implications, and the development of new hypotheses.