Consequences of different cut-off values for high-sensitivity cardiac troponin for risk stratification of patients suspected for NSTE-ACS with a modified HEART score.

IF 1.6 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Future cardiology Pub Date : 2023-08-01 Epub Date: 2023-09-13 DOI:10.2217/fca-2023-0038

Rudolf T Tolsma, Marion J Fokkert, Jan Paul Ottervanger, Dominique N van Dongen, Erik A Badings, Aize van der Sluis, Arnoud Wj Van't Hof, Robbert J Slingerland

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引用次数: 1

Abstract

Aim: This study aims to enhance prehospital risk assessment for suspected non-ST-elevation acute coronary syndrome (NSTE-ACS) patients using the HEART-score. By incorporating novel point-of-care high-sensitivity cardiac troponin devices, a modified HEART-score was developed and compared with the conventional approach. Patients & methods: Troponin points within the modified HEART-score are based on values below the limit of quantitation (LoQ), between the LoQ and 99th percentile and above the 99th percentile of the used device. A total HEART-score of three or lower is considered low-risk for major adverse cardiac events. Results & conclusion: The number of low-risk patients decreased based on the modified HEART-score. The sensitivity and negative predictive value increased which suggests increasing safety in ruling out patients with suspected NSTE-ACS.

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用改良的HEART评分对疑似NSTE-ACS患者进行风险分层的高敏肌钙蛋白不同临界值的后果。

目的：本研究旨在使用HEART评分加强对疑似非ST段抬高型急性冠状动脉综合征（NSTE-ACS）患者的院前风险评估。通过结合新型的护理点高灵敏度心肌肌钙蛋白设备，开发了一种改良的HEART评分，并与传统方法进行了比较。患者和方法：修改后的HEART评分中的肌钙蛋白分基于低于定量限（LoQ）、在LoQ和第99百分位之间以及高于所用器械的第99百位的值。HEART总分为3分或更低被认为是重大心脏不良事件的低风险。结果与结论：根据改良的HEART评分，低风险患者的数量有所减少。敏感性和阴性预测值增加，这表明排除疑似NSTE-ACS患者的安全性增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.80

自引率

5.90%

发文量

期刊介绍： Research advances have contributed to improved outcomes across all specialties, but the rate of advancement in cardiology has been exceptional. Concurrently, the population of patients with cardiac conditions continues to grow and greater public awareness has increased patients" expectations of new drugs and devices. Future Cardiology (ISSN 1479-6678) reflects this new era of cardiology and highlights the new molecular approach to advancing cardiovascular therapy. Coverage will also reflect the major technological advances in bioengineering in cardiology in terms of advanced and robust devices, miniaturization, imaging, system modeling and information management issues.