Ventilator support in the pretransplant period predisposes early graft failure after deceased donor liver transplantation.

IF 1.2 4区医学 Q3 SURGERY

Annals of Surgical Treatment and Research Pub Date : 2023-09-01 DOI:10.4174/astr.2023.105.3.141

Nuri Lee, Sora Cha, Jongman Kim, Yunmi Lee, Enjin Kang, Hyun Jung Kim, Seung Hui Hong, Jinsoo Rhu, Gyu-Seong Choi, Jae-Won Joh

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Abstract

Purpose: Deceased donor liver transplantation (DDLT) recipients in Korea are generally sicker due to an increasing organ shortage. In the present study, the risk factors for early 30-day liver graft failure after DDLT were identified.

Methods: From August 2017 to February 2021, 265 adult DDLTs were performed. The characteristics of patients with and without 30-day graft failure were compared.

Results: Liver graft failure occurred in 11 patients (17.7%) after DDLT. Baseline and perioperative characteristics of donors and recipients were not statistically significantly different between the 2 groups. The cumulative graft and overall survival rates at 6 months were 83.9% and 88.7%, respectively. Multivariate analysis showed ventilator support in the pretransplant period was a predisposing factor for 30-day graft failure after DDLT.

Conclusion: Present study indicates that cautious decision is required when allocating DDLT in critically ill patients on mechanical ventilatory support.

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移植前呼吸机支持易导致死亡供肝移植后早期移植衰竭。

目的:在韩国，由于器官日益短缺，死亡的供肝移植(DDLT)受者通常病情较重。在本研究中，确定了DDLT术后早期30天肝移植衰竭的危险因素。方法:2017年8月至2021年2月，对265例成人行ddlt。比较30天移植物衰竭患者和未移植物衰竭患者的特征。结果:DDLT术后肝移植衰竭11例(17.7%)。两组供体和受体的基线和围手术期特征差异无统计学意义。6个月累积移植和总生存率分别为83.9%和88.7%。多因素分析显示，移植前呼吸机支持是DDLT术后30天移植物衰竭的易感因素。结论:本研究提示危重患者在机械通气支持下分配DDLT时应谨慎决策。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Surgical Treatment and Research SURGERY-

CiteScore

2.30

自引率

7.10%

发文量

期刊介绍： Manuscripts to the Annals of Surgical Treatment and Research (Ann Surg Treat Res) should be written in English according to the instructions for authors. If the details are not described below, the style should follow the Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publications available at International Committee of Medical Journal Editors (ICMJE) website (http://www.icmje.org).