The Use of Enamel Matrix Derivative to Modulate Wound Healing of Peri-implant Soft Tissues.

IF 1.3 4区 医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE
Daniele Cardaropoli, Lorenzo Tamagnone, Alessandro Roffredo, Luigi Costanzo
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引用次数: 0

Abstract

Following implant placement, a soft tissue barrier will form at the healing abutment connection called peri-implant mucosa. The dimension of this anatomical structure seems to play a key role in maintaining long-term peri-implant and marginal bone level stability. In its early stages, soft tissue healing is a process involving many cellular and molecular events. Enamel matrix derivative (EMD) may improve and accelerate soft tissue wound healing and inflammatory resolution. In the present split-mouth randomized clinical trial, EMD was used to influence the early phase of soft tissue healing around dental implants placed with a single-stage approach into a completely healed ridge. A total of 60 implants were placed in 30 patients (2 implants per patient, one in the test group and one in the control group). In the test sites, EMD was administered around the healing abutment before soft tissues were sutured. Soft tissue healing index (HI) and secondary endpoints (clinical, radiographic, and patientreported outcomes) were measured. Better outcomes were recorded in patients receiving EMD for all parameters. The present results support the use of EMD to improve and accelerate soft tissue wound healing around implants.

牙釉质基质衍生物对种植体周围软组织创面愈合的调节作用。
种植体放置后,在愈合基台连接时,将形成软组织屏障定义种植体周围粘膜。这种解剖结构的尺寸似乎在维持种植体周围和边缘骨水平的长期稳定中起着关键作用。在早期阶段,软组织愈合是一个涉及许多细胞和分子事件的过程。牙釉质基质衍生物(EMD)可促进和促进软组织创面愈合和炎症消退。在目前的裂口随机临床试验中,EMD被用于影响牙种植体周围软组织愈合的早期阶段,采用单阶段入路进入完全愈合的牙嵴。30例患者共植入60颗种植体。试验组在缝合软组织前,在愈合基台周围施用EMD。测量软组织愈合指数(HI)以及次要终点(临床、放射学和PROMs)。在考虑所有参数时,接受EMD的患者记录了更好的结果。这里提出的数据支持使用EMD改善和加速种植体周围软组织伤口愈合。
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来源期刊
CiteScore
2.90
自引率
6.20%
发文量
113
审稿时长
6-12 weeks
期刊介绍: The International Journal of Periodontics & Restorative Dentistry will publish manuscripts concerned with all aspects of clinical periodontology, restorative dentistry, and implantology. This includes pertinent research as well as clinical methodology (their interdependence and relationship should be addressed where applicable); proceedings of relevant symposia or conferences; and quality review papers. Original manuscripts are considered for publication on the condition that they have not been published or submitted for publication elsewhere.
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