Vagal cardiac control in rats with LPS-induced lung injury

IF 1.9 4区医学 Q3 PHYSIOLOGY

Respiratory Physiology & Neurobiology Pub Date : 2023-10-01 DOI:10.1016/j.resp.2023.104120

I. Zila , M. Kolomaznik , P. Mikolka , P. Kosutova , B. Czippelova , M. Javorka , A. Calkovska

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Abstract

Heart rate variability (HRV) as an index of cardiac autonomic control in acute lung injury (ALI) has been evaluated in anaesthetized rats intratracheally instilled with bacterial lipopolysaccharide (LPS) and ventilated with breathing frequency of 60/min, 40% oxygen, inspiratory time 40%, tidal volume of 6 mL/kg. ECG was recorded before and 30, 60, 120, 180 and 240 min after LPS or saline (control) administration. HRV was quantified by time and frequency-domain analysis (mean RR interval, SDRR, RMSSD and spectral power in high frequency (HF) band. Lactate in plasma, and oxidative stress, IL-1β, IL-5, IL-12p70 and IL-13 and galectin-3 in heart tissue raised in LPS-injured rats. Overall HRV magnitude (SDRR) and marker of vagal heart rate control (RMSSD), as well as frequency domain parameter, spectral power HF was increased 120 and 180 min since ALI onset. In conclusion, LPS-induced ALI is accompanied by altered vagal cardiac control mediated by autonomic nervous system, likely based on the close relationship between immune response and vagally mediated autonomic nervous activity.

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LPS致肺损伤大鼠迷走神经的控制

在气管内滴注细菌脂多糖（LPS）并在呼吸频率为60/min、氧气含量为40%、吸气时间为40%、潮气量为6mL/kg的麻醉大鼠中，评价了急性肺损伤（ALI）中心率变异性（HRV）作为心脏自主神经控制的指标。在LPS或生理盐水（对照）给药前和给药后30、60、120、180和240分钟记录心电图。HRV通过时域和频域分析（平均RR间期、SDRR、RMSSD和高频（HF）波段的频谱功率）进行量化。血浆中的乳酸，以及LPS损伤大鼠心脏组织中的氧化应激、IL-1β、IL-5、IL-12p70、IL-13和半乳糖凝集素-3。自ALI发作120和180分钟以来，总体HRV幅度（SDRR）和迷走神经心率控制标志物（RMSSD）以及频域参数、频谱功率HF增加。总之，LPS诱导的ALI伴随着自主神经系统介导的迷走神经心脏控制的改变，这可能是基于免疫反应和迷走神经介导的自主神经活动之间的密切关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Respiratory Physiology & Neurobiology 医学-呼吸系统

CiteScore

4.80

自引率

8.70%

发文量

104

审稿时长

54 days

期刊介绍： Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.