Our ancestry dictates clonal architecture and skin cancer susceptibility

IF 31.7 1区生物学 Q1 GENETICS & HEREDITY

Nature genetics Pub Date : 2023-08-03 DOI:10.1038/s41588-023-01467-y

Marco De Dominici, James DeGregori

引用次数: 0

Abstract

Incidence of keratinocyte skin cancer varies markedly between populations living in different areas of the world. A detailed analysis of somatic mutations in the normal skin of individuals from the UK and Singapore reveals different patterns of clonal mutational landscapes that could contribute to differential risk.

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我们的祖先决定了克隆结构和皮肤癌症易感性。

生活在世界不同地区的人群的角质细胞皮肤癌发病率有明显差异。对英国和新加坡人正常皮肤中体细胞突变的详细分析揭示了克隆突变景观的不同模式，这可能是导致不同风险的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature genetics 生物-遗传学

CiteScore

43.00

自引率

2.60%

发文量

241

审稿时长

3 months

期刊介绍： Nature Genetics publishes the very highest quality research in genetics. It encompasses genetic and functional genomic studies on human and plant traits and on other model organisms. Current emphasis is on the genetic basis for common and complex diseases and on the functional mechanism, architecture and evolution of gene networks, studied by experimental perturbation. Integrative genetic topics comprise, but are not limited to: -Genes in the pathology of human disease -Molecular analysis of simple and complex genetic traits -Cancer genetics -Agricultural genomics -Developmental genetics -Regulatory variation in gene expression -Strategies and technologies for extracting function from genomic data -Pharmacological genomics -Genome evolution