Reprogramming iPSCs to study age-related diseases: Models, therapeutics, and clinical trials

IF 5.3 3区医学 Q2 CELL BIOLOGY

Mechanisms of Ageing and Development Pub Date : 2023-09-01 DOI:10.1016/j.mad.2023.111854

Filipa Esteves , David Brito , Ana Teresa Rajado , Nádia Silva , Joana Apolónio , Vânia Palma Roberto , Inês Araújo , Clévio Nóbrega , Pedro Castelo-Branco , José Bragança

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引用次数: 2

Abstract

The unprecedented rise in life expectancy observed in the last decades is leading to a global increase in the ageing population, and age-associated diseases became an increasing societal, economic, and medical burden. This has boosted major efforts in the scientific and medical research communities to develop and improve therapies to delay ageing and age-associated functional decline and diseases, and to expand health span. The establishment of induced pluripotent stem cells (iPSCs) by reprogramming human somatic cells has revolutionised the modelling and understanding of human diseases. iPSCs have a major advantage relative to other human pluripotent stem cells as their obtention does not require the destruction of embryos like embryonic stem cells do, and do not have a limited proliferation or differentiation potential as adult stem cells. Besides, iPSCs can be generated from somatic cells from healthy individuals or patients, which makes iPSC technology a promising approach to model and decipher the mechanisms underlying the ageing process and age-associated diseases, study drug effects, and develop new therapeutic approaches. This review discusses the advances made in the last decade using iPSC technology to study the most common age-associated diseases, including age-related macular degeneration (AMD), neurodegenerative and cardiovascular diseases, brain stroke, cancer, diabetes, and osteoarthritis.

查看原文本刊更多论文

重新编程iPSCs以研究年龄相关疾病:模型、治疗方法和临床试验

在过去几十年里，预期寿命出现了前所未有的增长，导致全球老龄化人口增加，与年龄有关的疾病成为日益严重的社会、经济和医疗负担。这推动了科学和医学研究界的重大努力，以开发和改进延缓衰老和与年龄有关的功能衰退和疾病的治疗方法，并延长健康寿命。通过对人类体细胞进行重编程来建立诱导多能干细胞(iPSCs)已经彻底改变了对人类疾病的建模和理解。与其他人类多能干细胞相比，iPSCs具有主要优势，因为它们不需要像胚胎干细胞那样破坏胚胎，也不像成体干细胞那样具有有限的增殖或分化潜力。此外，iPSC可以从健康个体或患者的体细胞中生成，这使得iPSC技术成为模拟和破译衰老过程和年龄相关疾病的机制、研究药物效应和开发新的治疗方法的有希望的方法。本文综述了近十年来利用iPSC技术研究最常见的年龄相关疾病的进展，包括年龄相关性黄斑变性(AMD)、神经退行性疾病和心血管疾病、脑中风、癌症、糖尿病和骨关节炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mechanisms of Ageing and Development 医学-老年医学

CiteScore

11.10

自引率

1.90%

发文量

审稿时长

32 days

期刊介绍： Mechanisms of Ageing and Development is a multidisciplinary journal aimed at revealing the molecular, biochemical and biological mechanisms that underlie the processes of aging and development in various species as well as of age-associated diseases. Emphasis is placed on investigations that delineate the contribution of macromolecular damage and cytotoxicity, genetic programs, epigenetics and genetic instability, mitochondrial function, alterations of metabolism and innovative anti-aging approaches. For all of the mentioned studies it is necessary to address the underlying mechanisms. Mechanisms of Ageing and Development publishes original research, review and mini-review articles. The journal also publishes Special Issues that focus on emerging research areas. Special issues may include all types of articles following peered review. Proposals should be sent directly to the Editor-in-Chief.