Bocar Baya , Ibrahim Sanogo , Mahamadou Kone , Dianguina Soumare , Kadidia Ouattara , Amadou Somboro , Mamadou Wague , Nadie Coulibaly , Isaac Koloma , Mariam Coulibaly , Mohamed Nantoume , Mamadou Perou , Kadidia Kone , Djeneba Coulibaly , Hawa Boukary Diarra , Bourahima Kone , Ayouba Diarra , Mamadou D. Coulibaly , Moumine Sanogo , Bassirou Diarra , Djeneba Dabitao
{"title":"Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali","authors":"Bocar Baya , Ibrahim Sanogo , Mahamadou Kone , Dianguina Soumare , Kadidia Ouattara , Amadou Somboro , Mamadou Wague , Nadie Coulibaly , Isaac Koloma , Mariam Coulibaly , Mohamed Nantoume , Mamadou Perou , Kadidia Kone , Djeneba Coulibaly , Hawa Boukary Diarra , Bourahima Kone , Ayouba Diarra , Mamadou D. Coulibaly , Moumine Sanogo , Bassirou Diarra , Djeneba Dabitao","doi":"10.1016/j.jctube.2023.100389","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><p>Contribution of host factors in mediating susceptibility to extrapulmonary tuberculosis is not well understood.</p></div><div><h3>Objective</h3><p>To examine the influence of patient sex on anatomical localization of extrapulmonary tuberculosis.</p></div><div><h3>Methods</h3><p>We conducted a retrospective cross-sectional study in Mali, West Africa. Hospital records of 1,304 suspected cases of extrapulmonary tuberculosis, available in TB Registry of a tertiary tuberculosis referral center from 2019 to 2021, were examined.</p></div><div><h3>Results</h3><p>A total of 1,012 (77.6%) were confirmed to have extrapulmonary tuberculosis with a male to female ratio of 1.59:1. Four clinical forms of EPTB predominated, namely pleural (40.4%), osteoarticular (29.8%), lymph node (12.5%), and abdominal TB (10.3%). We found sex-based differences in anatomical localization of extrapulmonary tuberculosis, with males more likely than females to have pleural TB (OR: 1.51; 95% CI [1.16 to 1.98]). Conversely, being male was associated with 43% and 41% lower odds of having lymph node and abdominal TB, respectively (OR: 0.57 and 0.59).</p></div><div><h3>Conclusion</h3><p>Anatomical sites of extrapulmonary tuberculosis differ by sex with pleural TB being associated with male sex while lymph node and abdominal TB are predominately associated with female sex. Future studies are warranted to understand the role of sex in mediating anatomical site preference of tuberculosis.</p></div>","PeriodicalId":37942,"journal":{"name":"Journal of Clinical Tuberculosis and Other Mycobacterial Diseases","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/ef/main.PMC10448223.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Tuberculosis and Other Mycobacterial Diseases","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2405579423000451","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
引用次数: 0
Abstract
Background
Contribution of host factors in mediating susceptibility to extrapulmonary tuberculosis is not well understood.
Objective
To examine the influence of patient sex on anatomical localization of extrapulmonary tuberculosis.
Methods
We conducted a retrospective cross-sectional study in Mali, West Africa. Hospital records of 1,304 suspected cases of extrapulmonary tuberculosis, available in TB Registry of a tertiary tuberculosis referral center from 2019 to 2021, were examined.
Results
A total of 1,012 (77.6%) were confirmed to have extrapulmonary tuberculosis with a male to female ratio of 1.59:1. Four clinical forms of EPTB predominated, namely pleural (40.4%), osteoarticular (29.8%), lymph node (12.5%), and abdominal TB (10.3%). We found sex-based differences in anatomical localization of extrapulmonary tuberculosis, with males more likely than females to have pleural TB (OR: 1.51; 95% CI [1.16 to 1.98]). Conversely, being male was associated with 43% and 41% lower odds of having lymph node and abdominal TB, respectively (OR: 0.57 and 0.59).
Conclusion
Anatomical sites of extrapulmonary tuberculosis differ by sex with pleural TB being associated with male sex while lymph node and abdominal TB are predominately associated with female sex. Future studies are warranted to understand the role of sex in mediating anatomical site preference of tuberculosis.
期刊介绍:
Journal of Clinical Tuberculosis and Mycobacterial Diseases aims to provide a forum for clinically relevant articles on all aspects of tuberculosis and other mycobacterial infections, including (but not limited to) epidemiology, clinical investigation, transmission, diagnosis, treatment, drug-resistance and public policy, and encourages the submission of clinical studies, thematic reviews and case reports. Journal of Clinical Tuberculosis and Mycobacterial Diseases is an Open Access publication.