Relationship between patient sex and anatomical sites of extrapulmonary tuberculosis in Mali

IF 1.9 Q3 INFECTIOUS DISEASES
Bocar Baya , Ibrahim Sanogo , Mahamadou Kone , Dianguina Soumare , Kadidia Ouattara , Amadou Somboro , Mamadou Wague , Nadie Coulibaly , Isaac Koloma , Mariam Coulibaly , Mohamed Nantoume , Mamadou Perou , Kadidia Kone , Djeneba Coulibaly , Hawa Boukary Diarra , Bourahima Kone , Ayouba Diarra , Mamadou D. Coulibaly , Moumine Sanogo , Bassirou Diarra , Djeneba Dabitao
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引用次数: 0

Abstract

Background

Contribution of host factors in mediating susceptibility to extrapulmonary tuberculosis is not well understood.

Objective

To examine the influence of patient sex on anatomical localization of extrapulmonary tuberculosis.

Methods

We conducted a retrospective cross-sectional study in Mali, West Africa. Hospital records of 1,304 suspected cases of extrapulmonary tuberculosis, available in TB Registry of a tertiary tuberculosis referral center from 2019 to 2021, were examined.

Results

A total of 1,012 (77.6%) were confirmed to have extrapulmonary tuberculosis with a male to female ratio of 1.59:1. Four clinical forms of EPTB predominated, namely pleural (40.4%), osteoarticular (29.8%), lymph node (12.5%), and abdominal TB (10.3%). We found sex-based differences in anatomical localization of extrapulmonary tuberculosis, with males more likely than females to have pleural TB (OR: 1.51; 95% CI [1.16 to 1.98]). Conversely, being male was associated with 43% and 41% lower odds of having lymph node and abdominal TB, respectively (OR: 0.57 and 0.59).

Conclusion

Anatomical sites of extrapulmonary tuberculosis differ by sex with pleural TB being associated with male sex while lymph node and abdominal TB are predominately associated with female sex. Future studies are warranted to understand the role of sex in mediating anatomical site preference of tuberculosis.

Abstract Image

马里肺外结核患者性别与解剖部位的关系
背景宿主因素在介导肺外结核易感性中的作用尚不清楚。目的探讨患者性别对肺外结核解剖定位的影响。方法我们在西非马里进行了一项回顾性横断面研究。对2019年至2021年三级结核病转诊中心结核病登记处提供的1304例肺外结核病疑似病例的医院记录进行了检查。结果1012例(77.6%)确诊为肺外结核,男女比例为1.59:1。EPTB主要有四种临床形式,即胸膜结核(40.4%)、骨关节结核(29.8%)、淋巴结结核(12.5%)和腹部结核(10.3%)。我们发现肺外结核的解剖定位存在基于性别的差异,男性比女性更有可能患胸膜结核(OR:1.51;95%CI[1.16至1.98])。相反,结论肺外结核的解剖部位因性别而异,胸膜结核与男性相关,而淋巴结和腹部结核主要与女性相关。未来的研究有必要了解性别在结核病解剖部位偏好中的作用。
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来源期刊
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases Medicine-Pulmonary and Respiratory Medicine
CiteScore
4.00
自引率
5.00%
发文量
44
审稿时长
30 weeks
期刊介绍: Journal of Clinical Tuberculosis and Mycobacterial Diseases aims to provide a forum for clinically relevant articles on all aspects of tuberculosis and other mycobacterial infections, including (but not limited to) epidemiology, clinical investigation, transmission, diagnosis, treatment, drug-resistance and public policy, and encourages the submission of clinical studies, thematic reviews and case reports. Journal of Clinical Tuberculosis and Mycobacterial Diseases is an Open Access publication.
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