The effect of SARS-CoV-2 variants on the plasma oxylipins and PUFAs of COVID-19 patients

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators Pub Date : 2023-08-24 DOI:10.1016/j.prostaglandins.2023.106770

Denise Biagini , Paolo Oliveri , Andreina Baj , Daniela Dalla Gasperina , Francesca Drago Ferrante , Tommaso Lomonaco , Silvia Ghimenti , Alessio Lenzi , Andrea Bonini , Federico Vivaldi , Camille Oger , Jean-Marie Galano , Laurence Balas , Thierry Durand , Fabrizio Maggi , Fabio Di Francesco

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Abstract

Oxylipins are important signalling compounds that are significantly involved in the regulation of the immune system and the resolution of inflammation. Lipid metabolism is strongly activated upon SARS-CoV-2 infection, however the modulating effects of oxylipins induced by different variants remain unexplored.

Here, we compare the plasma profiles of thirty-seven oxylipins and four PUFAs in subjects infected with Wild-type, Alpha (B.1.1.7), Delta (B.1.617.2), and Omicron (B.1.1.529) variants.

The results suggest that oxidative stress and inflammation resulting from COVID-19 were highly dependent on the SARS-CoV-2 variant, and that the Wild-type elicited the strongest inflammatory storm. The Alpha and Delta variants induced a comparable lipid profile alteration upon infection, which differed significantly from Omicron. The latter variant increased the levels of pro-inflammatory mediators and decreased the levels of omega-3 PUFA in infected patients.

We speculate that changes in therapeutics, vaccination, and prior infections may have a role in the alteration of the oxylipin profile besides viral mutations. The results shed new light on the evolution of the inflammatory response in COVID-19.

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SARS-CoV-2变异对COVID-19患者血浆氧脂素和PUFAs的影响

氧化脂素是一种重要的信号化合物，在免疫系统的调节和炎症的消退中起着重要的作用。脂质代谢在SARS-CoV-2感染时被强烈激活，但不同变体诱导的氧化脂素的调节作用仍未被探索。在这里，我们比较了感染野生型、α (B.1.1.7)、Delta (B.1.617.2)和Omicron (B.1.1.529)变体的受试者的37种氧脂素和4种PUFAs的血浆谱。结果表明，COVID-19引起的氧化应激和炎症高度依赖于SARS-CoV-2变异，其中野生型引发的炎症风暴最强。α和δ变异在感染后引起类似的脂质谱改变，这与Omicron有显著不同。在感染患者中，后一种变异增加了促炎介质的水平，降低了omega-3 PUFA的水平。我们推测，除了病毒突变外，治疗方法、疫苗接种和先前感染的变化也可能对氧脂质谱的改变起作用。这些结果为COVID-19炎症反应的演变提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostaglandins & other lipid mediators 生物-生化与分子生物学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators. Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology. Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.