Opioid dispensing in relation to arthroscopic knee surgery in Denmark from 2006 to 2018.

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Danish medical journal Pub Date : 2023-08-23

Jonas Bloch Thorlund, Matilde Lundberg, Jindong Ding Petersen, Martin Englund, Bjarke Viberg, Frans Boch Waldorff, Jens Søndergaard

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引用次数: 0

Abstract

Introduction: In the US, opioids are commonly prescribed after arthroscopic knee surgery. We aimed to investigate opioid dispensing in relation to arthroscopic knee surgeries from 2006 to 2018 in Denmark.

Methods: In Danish registries, we identified patients (≥ 15 years old) having arthroscopic knee surgery (anterior cruciate ligament (ACL) reconstruction; meniscal surgery; cartilage resection; synovectomy and diagnostic arthroscopy) between 1 January 2006 and 31 December 2018 and opioid dispensing (oral morphine equivalents (OMEQ)) within seven days after discharge from surgery.

Results: Among 218,940 patients, 15,263 (7%) had an opioid dispensed within seven days after being discharged following surgery. The opioid dispensing incidence (per 1,000 persons/year) increased during the study period for all procedures. This trend was more pronounced for ACL reconstruction, which recorded an increase from 86 (95% confidence interval (CI): 75-99) in 2006 to 278 (95% CI: 255-301) in 2018, corresponding to 9% and 28% of ACL patients, respectively. In the same period, the average amount of opioids dispensed within the first seven days after discharge decreased (change: 70.0 OMEQ (95% CI: 12.4-127.5)). Tramadol and oxycodone were the most commonly dispensed opioids.

Conclusion: About 7% of patients had an opioid dispensed within the first seven days after discharge following arthroscopic knee surgery. The incidence of opioids dispensed increased for all investigated procedures from 2006 to 2018. In the same period, the average amount of opioids dispensed within the first seven days after discharge decreased.

Funding: None.

Trial registration: Not relevant.

本刊更多论文

2006年至2018年丹麦与关节镜膝关节手术相关的阿片类药物分配

在美国，阿片类药物通常在膝关节镜手术后使用。我们的目的是调查2006年至2018年丹麦关节镜膝关节手术中阿片类药物分配的相关情况。方法:在丹麦的登记处，我们确定了接受关节镜膝关节手术(前交叉韧带(ACL)重建;半月板手术;软骨切除;2006年1月1日至2018年12月31日期间进行滑膜切除术和诊断性关节镜检查，并在手术出院后7天内分发阿片类药物(口服吗啡当量(OMEQ))。结果:在218,940例患者中，15,263例(7%)在术后出院后7天内配发了阿片类药物。在所有程序的研究期间，阿片类药物分配发生率(每1000人/年)增加。这一趋势在ACL重建中更为明显，从2006年的86例(95%置信区间(CI): 75-99)增加到2018年的278例(95% CI: 255-301)，分别对应于9%和28%的ACL患者。在同一时期，出院后7天内阿片类药物的平均配药量减少(变化:70.0 OMEQ (95% CI: 12.4-127.5))。曲马多和羟考酮是最常用的阿片类药物。结论:约7%的患者在膝关节镜手术后出院后7天内配发了阿片类药物。从2006年到2018年，所有调查程序的阿片类药物分配发生率都有所增加。在同一时期，出院后头7天内阿片类药物的平均配药量下降。资金:没有。试验注册:不相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Danish medical journal MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

6.20%

发文量

审稿时长

3-8 weeks

期刊介绍： The Danish Medical Journal (DMJ) is a general medical journal. The journal publish original research in English – conducted in or in relation to the Danish health-care system. When writing for the Danish Medical Journal please remember target audience which is the general reader. This means that the research area should be relevant to many readers and the paper should be presented in a way that most readers will understand the content. DMJ will publish the following articles: • Original articles • Protocol articles from large randomized clinical trials • Systematic reviews and meta-analyses • PhD theses from Danish faculties of health sciences • DMSc theses from Danish faculties of health sciences.