Visuospatial and Verbal Memory Differences in Amish Individuals With Alzheimer Disease and Related Dementias.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2023-07-01 Epub Date: 2023-08-02 DOI:10.1097/WAD.0000000000000570

Michael B Prough, Andrew Zaman, Laura J Caywood, Jason E Clouse, Sharlene D Herington, Susan H Slifer, Daniel A Dorfsman, Larry A Adams, Reneé A Laux, Yeunjoo E Song, Audrey Lynn, Denise Fuzzell, Sarada L Fuzzell, Sherri D Miller, Kristy Miskimen, Leighanne R Main, Michael D Osterman, Paula Ogrocki, Alan J Lerner, Jeffery M Vance, Jonathan L Haines, William K Scott, Margaret Pericak-Vance, Michael L Cuccaro

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引用次数: 0

Abstract

Background: Verbal and visuospatial memory impairments are common to Alzheimer disease and Related Dementias (ADRD), but the patterns of decline in these domains may reflect genetic and lifestyle influences. The latter may be pertinent to populations such as the Amish who have unique lifestyle experiences.

Methods: Our data set included 420 Amish and 401 CERAD individuals. Sex-adjusted, age-adjusted, and education-adjusted Z-scores were calculated for the recall portions of the Constructional Praxis Delay (CPD) and Word List Delay (WLD). ANOVAs were then used to examine the main and interaction effects of cohort (Amish, CERAD), cognitive status (case, control), and sex on CPD and WLD Z-scores.

Results: The Amish performed better on the CPD than the CERAD cohort. In addition, the difference between cases and controls on the CPD and WLD were smaller in the Amish and Amish female cases performed better on the WLD than the CERAD female cases.

Discussion: The Amish performed better on the CPD task, and ADRD-related declines in CPD and WLD were less severe in the Amish. In addition, Amish females with ADRD may have preferential preservation of WLD. This study provides evidence that the Amish exhibit distinct patterns of verbal and visuospatial memory loss associated with aging and ADRD.

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阿米什人阿尔茨海默病及相关痴呆症的视觉空间和言语记忆差异。

背景：言语和视觉空间记忆障碍在阿尔茨海默病和相关痴呆症（ADRD）中很常见，但这些领域的衰退模式可能反映了遗传和生活方式的影响。后者可能与阿米什人等拥有独特生活体验的人群有关。方法：我们的数据集包括420名阿米什人和401名CERAD患者。计算结构实践延迟（CPD）和单词列表延迟（WLD）的回忆部分的性别调整、年龄调整和教育调整Z分数。然后使用方差分析来检验队列（Amish，CERAD）、认知状态（病例、对照）和性别对CPD和WLD Z评分的主要影响和交互作用。结果：Amish在CPD上的表现优于CERAD队列。此外，在阿米什人中，病例和对照组在CPD和WLD方面的差异较小，阿米什女性病例在WLD方面表现优于CERAD女性病例。讨论：阿米什人在CPD任务中表现更好，与ADRD相关的CPD和WLD下降在阿米什语中不那么严重。此外，患有ADRD的阿米什女性可能优先保存WLD。这项研究提供了证据，证明阿米什人表现出与衰老和ADRD相关的言语和视觉空间记忆丧失的不同模式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.