The second heart field: the first 20 years.

IF 2.7 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Mammalian Genome Pub Date : 2023-06-01 DOI:10.1007/s00335-022-09975-8

Ke Zhao, Zhongzhou Yang

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Abstract

In 2001, three independent groups reported the identification of a novel cluster of progenitor cells that contribute to heart development in mouse and chicken embryos. This population of progenitor cells was designated as the second heart field (SHF), and a new research direction in heart development was launched. Twenty years have since passed and a comprehensive understanding of the SHF has been achieved. This review provides retrospective insights in to the contribution, the signaling regulatory networks and the epithelial properties of the SHF. It also includes the spatiotemporal characteristics of SHF development and interactions between the SHF and other types of cells during heart development. Although considerable efforts will be required to investigate the cellular heterogeneity of the SHF, together with its intricate regulatory networks and undefined mechanisms, it is expected that the burgeoning new technology of single-cell sequencing and precise lineage tracing will advance the comprehension of SHF function and its molecular signals. The advances in SHF research will translate to clinical applications and to the treatment of congenital heart diseases, especially conotruncal defects, as well as to regenerative medicine.

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第二个心脏领域:前20年。

2001年，三个独立的研究小组报告了在小鼠和鸡胚胎中发现的一组促进心脏发育的新祖细胞。该祖细胞群被命名为第二心脏场(second heart field, SHF)，为心脏发育开辟了新的研究方向。20年过去了，我们对SHF有了全面的了解。本文回顾了SHF的作用、信号调节网络和上皮性质。它还包括SHF发育的时空特征以及心脏发育过程中SHF与其他类型细胞之间的相互作用。尽管研究SHF的细胞异质性以及其复杂的调控网络和未定义的机制还需要大量的努力，但人们期望单细胞测序和精确谱系追踪的新兴新技术将促进对SHF功能及其分子信号的理解。SHF研究的进展将转化为临床应用和治疗先天性心脏病，特别是圆锥体缺陷，以及再生医学。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mammalian Genome 生物-生化与分子生物学

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Mammalian Genome focuses on the experimental, theoretical and technical aspects of genetics, genomics, epigenetics and systems biology in mouse, human and other mammalian species, with an emphasis on the relationship between genotype and phenotype, elucidation of biological and disease pathways as well as experimental aspects of interventions, therapeutics, and precision medicine. The journal aims to publish high quality original papers that present novel findings in all areas of mammalian genetic research as well as review articles on areas of topical interest. The journal will also feature commentaries and editorials to inform readers of breakthrough discoveries as well as issues of research standards, policies and ethics.