Epidemiology of canine cutaneous round cell tumours on the canary archipelago in Spain.

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES
José Rodríguez, Ángelo Santana, Marisa Andrada Borzollino, Pedro Herráez, David R Killick, Antonio Espinosa de Los Monteros
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Abstract

In this study we undertook a comprehensive analysis of a Pet Tumour Registry of the Canary Archipelago (PTR-CA) in Spain to investigate the epidemiology of canine cutaneous round cell tumours. From a database of 2526 tumours collected from 2003 to 2020, we conducted a longitudinal analysis of the main trends in diagnosis, age, multiplicity and anatomical distribution as well as a case-control study comparing these cases with the contemporaneous canine population of the Canary Archipelago to analyse breed distribution. In line with former studies, we found histiocytomas mostly affect young dogs (2, IQR 1-5) and mast cell tumours affect middle-to-old dogs (8, IQR 6-10) with grade 1 affecting at younger ages (6.5, IQR 6-8) than both grade 2 (8, IQR 6-10 years) and grade 3 (9, IQR 7-11). Histiocytomas and plasmacytomas showed a similar anatomical distribution appearing mainly on the face, head and neck regions while mast cell tumours occur mainly on limbs and trunk. Higher risk for mast cell tumours and histiocytomas were found for Bulldog-related breeds such as Boxer (ORMCT  = 23.61, CI95%: 19.12-29.15, ORHCT  = 10.17, CI95%: 6.60-15.67), Boston Terrier (ORMCT 19.47, CI95%: 7.73-49.05, ORHCT 32.61, CI95%: 11.81-90.07) and Pug (ORMCT 8.10, CI95%: 5.92-11.07, ORHCT 7.87, CI95%: 4.66-13.28) while Chihuahua dogs showed significantly less risk (ORMCT 0.18, CI95%: 0.09-0.33, ORHCT 0.41, CI95%: 0.21-0.78). Notably, the Canarian Mastiff, a local breed, had a low risk of suffering from a mast cell tumour which raises the question of whether this relates to a genetic peculiarity of this breed or some husbandry and environmental factor.

西班牙加那利群岛犬皮肤圆细胞瘤的流行病学。
在这项研究中,我们对西班牙加那利群岛宠物肿瘤登记处(PTR-CA)进行了全面分析,以调查犬皮肤圆形细胞肿瘤的流行病学。从2003年至2020年收集的2526个肿瘤数据库中,我们对诊断、年龄、多样性和解剖分布的主要趋势进行了纵向分析,并将这些病例与加那利群岛同期犬群进行了病例对照研究,以分析品种分布。与之前的研究一致,我们发现组织细胞瘤主要影响幼犬(2,IQR 1-5),肥大细胞瘤影响中老年犬(8,IQR 6-10),其中1级影响年龄较小(6.5,IQR 6-8),而2级(8,IQR 6-10岁)和3级(9,IQR 7-11)。组织细胞瘤和浆细胞瘤解剖分布相似,主要出现在面部、头部和颈部,而肥大细胞瘤主要发生在四肢和躯干。与斗牛犬相关的品种如Boxer (ORMCT = 23.61, CI95%: 19.12-29.15, ORHCT = 10.17, CI95%: 6.60-15.67), Boston Terrier (ORMCT 19.47, CI95%: 7.73-49.05, ORHCT 32.61, CI95%: 11.81-90.07)和Pug (ORMCT 8.10, CI95%: 5.92-11.07, ORHCT 7.87, CI95%: 4.66-13.28)患肥大细胞瘤和组织细胞瘤的风险较高,而吉娃娃犬的风险较低(ORMCT 0.18, CI95%: 0.09-0.33, ORHCT 0.41, CI95%: 0.21-0.78)。值得注意的是,当地品种加那利獒犬患肥大细胞瘤的风险很低,这引发了一个问题,这是否与该品种的遗传特性有关,还是与某些饲养和环境因素有关。
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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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