Amide-to-Chloroalkene Substitution for Peptide Backbone Modification to Enhance Membrane Permeability

已完结 10 由 Tony 发布于 2026/5/31 16:07:45

DOI:10.1021/acs.jmedchem.5c02090
作者：Sayuri Takeo,?, ,?Mio Takeda,?, ,?Chihiro Iio,?, ,?Ai Sakakibara,?, ,?Showmitra Saha,?, ,?Natsuki Shibata,?, ,?Yuki Yamazaki,?, ,?Takahiro Fujii,?, ,?Ryuhei Harada,?, ,?Kohei Sato,?, ,?Nobuyuki Mase,?
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Herein, we report a systematic evaluation of backbone modification strategies to enhance peptide membrane permeability, focusing on chloroalkene dipeptide isosteres (CADIs) as amide bond sur

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