Restoring circadian rhythms in the hypothalamic paraventricular nucleus reverses aging biomarkers and extends lifespan in male mice

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DOI:10.1016/j.cell.2026.01.016
作者：Haijiao Zhao, Meimei Liao, Ran Huo, Ting He, Hongni Tian, Zeqi Li, Chen Chen, Ziqing Yu, Juan Chai, Xiaocui Song, Ruichao Shao, Shuhua Ying, Wen Gao, Ling Liu, Di Sang, Qi Li, Haohong Li, Fengchao Wan
文献类型：期刊论文
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Elsevier

Abstract：Age-related circadian disruptions accelerate physiological decline and shorten lifespan. Enhancing circadian amplitude has emerged as a promising strategy for ameliorating age-associated dis

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