In Silico Enabled Discovery of KAI-11101, a Preclinical DLK Inhibitor for the Treatment of Neurodegenerative Disease and Neuronal Injury

已完结 10 由哈哈哈哈发布于 2026/5/19 9:55:10

DOI:10.1021/acs.jmedchem.4c02074
作者：H. Rachel Lagiakos, Yefen Zou, Hideyuki Igawa, Eric Therrien, Morgan Lawrenz, Mitsunori Kato, Mats Svensson, Felicia Gray, Kristian Jensen, Markus K. Dahlgren, Robert D. Pelletier, Karen Dingley, Jeff
文献类型：期刊论文
补充材料：只需要正文

American Chemical Society (ACS)

Abstract：Dual leucine zipper kinase (DLK), expressed primarily in neuronal cells, is a regulator of neuronal degeneration in response to cellular stress from chronic disease or neuronal injury. This

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